Clark School Home UMD
wie homepage

News Story

Dr. Silvia Muro, Genisphere Partner to Advance Drug Delivery Systems

Bookmark and Share


Dr. Silvia Muro, Genisphere Partner to Advance Drug Delivery Systems

Dr. Silvia Muro
Dr. Silvia Muro

Genisphere LLC, provider of the 3DNA®drug delivery platform, has signed a collaborative and sponsored research agreement with the University of Maryland, through Fischell Department of Bioengineering (BIOE) associate professor Silvia Muro.

The overall goal of the partnership is to study the pharmacokinetics and pharmacodynamics of various 3DNA designs and formulations after in vivo administration. Additional aims involve targeting diseases of the vasculature as well as inflammatory responses, demonstrating various methods of endocytosis via appropriate targeting moieties, and studying the mode and mechanism of 3DNA crossing the blood-brain barrier. 

Muro is a recognized expert on cellular and subcellular interactions and transport, as well as in vivo targeting, pharmacokinetics, biodistribution, and effects of drugs and drug delivery vehicles. She has also developed proprietary technologies and methods in these fields.

Muro was first to show Genisphere's DNA-based nanodevices could be modified to induce specific uptake mechanisms for intracellular delivery of diverse compounds. A follow-up publication in 2014 validated her prior demonstration of 3DNA as a drug delivery nanocarrier.

"We have previous evidence of active targeting of 3DNA after intravenous injection," Muro said. "The goal now is to expand our in vivo studies to additional animal models, evaluate different sized 3DNA molecules, study the impact of targeting, and compare routes of administration. We are looking forward to learning more about these nanoreagents and how they interact with cells as they deliver their cargo. Our early focus on pharmacokinetics and biodistribution will drive how the unique properties of this DNA nanoscaffold may be utilized to effectively reach diseased cells and cross the blood-brain barrier. My lab has developed several tools to study nanoparticles and their interaction with biological membranes and barriers."

"This collaboration, a decade in the making, is key for Genisphere," said Bob Getts, Genisphere's Chief Science Officer. "We want to build on the foundation of knowledge we have accumulated over the last few years integrating Dr. Muro's experience with 3DNA nanocarriers as well as her broad expertise in the targeted delivery and nanotechnology fields. The publications we expect from this partnership will be fundamental, and will also provide specific guidance for future applications as we build our drug pipeline in cardiovascular disease, oncology and neurotherapeutics." 

Related Articles:
Kofinas, Muro Honored for Research
Muro Wins $1.72M National Institutes of Health R01 Grant

April 26, 2017


Prev   Next

Current Headlines

Li Named to Forbes' "30 Under 30" List

Students Get Ready for Advanced Degrees at GEM GRAD Lab

UMD/MSE Graduate Student is an MRS Graduate Student Award Finalist This Fall

ME Alumni Awarded Clark School Glenn L. Martin Medal

Mentors Needed for Women's Hackathon!

ChBE Students Benefit from Co-op Experience

UMD Solar Decathlon Team Takes 1st Place in the U.S., 2nd Place in the World

Building Together Announcement Garners Extensive Media Coverage

News Resources

Return to Newsroom

Search News

Archived News

Events Resources

Events Calendar

Additional Resources

UM Newsdesk

Faculty Experts